Today, there are lots of discussions about the positives that peptides bring to the bodybuilding industry. Unfortunately, there is no sufficient information or even scientific evidence on peptides and their effects on the human body.
For athletes and bodybuilders who want to quicken their muscle recovery while they heal injuries, the synthetic version of Thymosin Beta-4 peptide known as TB-500 can help.
Today, many TB 500 reviews note that this peptide imitates the effects of TB4 created in the thymus gland. TB4 is known for accelerating the injury recovery time.
Also, research and even reviews on TB-500 peptide imply that it can help boost your cardiovascular health as well as wound-healing in athletes.
Such is exciting news for fitness enthusiasts who like pushing their bodies to the max.
But what does science say about the TB 500 peptide?
In this review, we’ll provide you with factual information about the TB 500 peptide and how it can help you. In addition to the benefits, we will also look at any drawbacks linked to this peptide and everything you need to know about it.
TB 500 History
Thymosin was discovered in the mid-1960s in New York’s Albert Einstein College of Medicine, as Allan Goldstein from the Lab of Abraham White was studying the function of the thymus in the development of vertebrates immune system. From that time, Dr Goldstein established a company that develops thymosin alpha-1 that is meant for increasing your immune cell activity, and TB500( thymosin beta 4) that promotes cell repair and wound healing.
There’s been extensive use of TB-500 on racehorses for preventing the formation of adhesions, although it’s not a prescription veterinary medicine. This is an injectable peptide that has limited human use.
Typically, TB500 is limited to people who like experimenting on drugs. However, reports of the use of thymosin on humans date back to 1974 – when the first person, a young girl, received the injections of thymosin as she was diagnosed to not have the function of her thymus gland.
The use of TB-500 has shown to provide many effects that are similar to those from growth hormone (GH), which include:
- Enhanced strength resulting from muscle growth
- Improved endurance
- Accelerated the healing of wounds
- Reduces inflammation or acute or/and chronic pain
- Increases flexibility
- Enhances hair growth
We’ll later look at these benefits in more details, but first…
What is Thymosin Beta 4
This is a natural protein found in humans and is encoded by TMSB4X gene. It’s also called Timbetasin as was published by the WHO (World Health Organization). Thymosin Beta 4 comprises of 43 amino acids that have the molecular weight of 4,921 g/mol.
This peptide is regenerative, water-soluble, and can be found in all cell types and tissues except in your red blood cells. But, it is found in other body fluids like saliva, tears, cerebrospinal fluid and wound fluids.
What is TB-500
TB-500, as it’s commonly called, is a vet preparation that is used on racehorses for preventing adhesions formation. This is a synthetic variation of Thymosin Beta 4. The main component is a peptide segment I.e (17)LKKTETQ(23), that is also the part in Thymosin Beta 4 that binds with actin. This part also exhibits effects like cell migration, angiogenesis, and wound healing.
The main purpose of tb4 (Thymosin Beta 4) is for up-regulating the cell-building proteins like Actin. Cell migration and multiplication is enhanced through the up-regulation of Actin. As a result, it helps in various ways like regulating inflammations and building conduits for new blood vessels.
When compared to other repair peptides such as the growth factor, Thymosin Beta 4 is different, when it concerns the migration and localization of keratinocyte- endothelial.
This peptide has a high versatility that this gets to its low molecular size and weight. As a result, it does not bind to the extracellular matrix. Due to this, Thymosin Beta 4 can potentially circulate over long distances through the tissues inside your body and identify the injured areas that need repair.
Also, its users have reported other positive impacts like improved flexibility, regrowing of hair and darkening of grey hairs.
What’s more, the healing benefits of TB 500 are evident skin, eyes, muscles, bones, ligaments, tendons, among other body parts.
How TB-500 Benefits Bodybuilders and Athletes
Typically, bodybuilders and even athletes get injured often and they’re forced to spend their productive time for healing. In these instances, TB 500 can be a boon for them, since it’s best-known for its impressive healing properties. In essence, this peptide is not used for mass gain, rather it’s used for quickening the recovery of all kinds of injury.
Also, it acts on uninjured body parts and helps tone your muscles. While there have been different claims on the benefits of TB 500 when it concerns muscle gains, the conclusion hasn’t been drawn yet.
What’s more, TB 500 peptides can help increase your vigour and stamina which then helps increase your productivity.
Benefits of Using TB 500
In this segment of our TB 500 review, we will be looking at the benefits you get to enjoy by using this compound. Studies on humans using TB 500 have been done and so far, there has been no complaints reported by the participants. And this is even after discontinuing the use of this peptide supplement.
So why use TB500? Here’s a look at why this supplement is worth trying.
Improves Endurance And Boosts Stamina
If you want to boost your endurance and stamina during workouts, then you may need to include TB 500 into your exercise routines. This supplements will massively improve your output in gym sessions. Even users have noted to have felt powerful and stronger during their training routines.
Supports muscle tissues Recovery
TB500 will not only support muscle tissues recovery but all tissues in general. You’ll notice your recovery time is cut by half after you include TB 500 into your exercise routine.
Promotes Hair Growth
This supplement helps restore healthy hair growth for men who suffer from Alopecia or baldness (also called a receding hairline). Also can benefit those who’ve lost their hair due to some disease.
It Helps tone your Muscles
When you are TB500, you will not have to spend hours at the gym trying to tone your muscles as TB 500 can naturally promote muscle toning.
Even some of its users have reported the growth of lean muscle growth.
While this is not a wonder drug, note that with your new-found strength, you can even smash your personal best records in a flash. Some users have noted that they were able to beat their best records within four weeks of administering this compound.
Enhances Your Stem Cells
Stem cells have been known to help repair nearly any damage done to your body, and this includes neurological damage. Since TB 500 can positively impact your stem cells, it can help support them into doing their job with efficiency. This, in turn, helps promote healing effects in your whole body.
While this is the hallmark of nearly all the available peptides, so this benefit does not come as a surprise on this list.
Helps heal stomach ulcers and even lesions.
There are people who try using TB 500 for curing their acute wounds which tend to heal slowly; or foe curing their deep wounds, that may or may not appear to heal.
Thanks to this particular property of TB500, millions of people from across the globe have benefited from this peptide. These people have been suffering from slow wound-healing due to many different reasons.
Any possible Side Effects?
Present-day research on TB-500 supplement shows contradictory results. By this we mean, there have been studies that indicate that it could exacerbate the growth of cancer cells, while other studies show that it can prevent cancer.
Also, physicians have noticed higher levels of Thymosin in cancer patients compared to healthy individuals, and this has sparked some rumours about TB-500 increasing cancer cells growth.
However, further research indicated that with higher levels of Thymosin Beta-4 the production of white blood cells was increased.
That’s why it shows up in sites with cancer cells. Thus, instead of fueling the fire it instead boosts your body’s immune response.
From this point, there isn’t much info on TB-500 since few studies have been carried out on it.
Even then, the most popular side-effect that many athletes and bodybuilders who use TB500 have observed is that of experiencing extreme tiredness.
Some users report getting a head rush as soon as they injecting it, but this feeling only lasts for some minutes before everything return to normal.
TB 500 Dosage
The standard dose of TB 500 often ranges between 4 – 10 milligrams which should be taken twice a week. Usually, this is the starting dose that you have to take in the 4- 6 weeks, which allows your system to adjust to the supplement. Thereafter, you can administer 2-3 milligrams once per week for purposes of maintenance.
Still, in the maintenance protocol, you may use it once a month. And the latter stages of this procedure may be used during your training season, and when prepping for a competition. It can help prevent injury as well as add to faster recovery while you push yourself past your limits.
We must point out that, the dosing protocol discussed above is the most popular one, but it’s not necessarily the standard dosage recommendation.
So far, there’s no standard dosing procedure. All the information we’ve shared is based on finding what has worked to date for animals engaging in athletic training.
Experts recommend that the TB 500 dosage and overall length of treatment need to be based on your specific needs.
How To Administer TB-500 Dosage
TB 500 peptide comes in ampoules and is in dried powder form (also called a lyophilized form). This supplement needs to be reconstituted into a solution form using bacteriostatic water. And this makes it possible to administer it.
TB-500 was developed to be introduced to your body as an injected into your skin using sterile insulin-type syringes.
You can easily buy these syringes from most pharmacies and drugstores, and you can also buy them in bulk online for regular use.
Your TB-500 dose must be mixed with some plain sterile water which helps dilute the supplement before injection.
Use of Bacteriostatic water is the best alternative since the TB-500 moves more quickly into your bloodstream once you diluted with it.
Steps for getting the right dosage
Follow these simple steps to get the right TB -500 peptide dosage:
- Place 1 ml of the sterile water into your syringe marked at 100 unit measurements.
- Then inject your syringe into the TB-500 vial dosage powder.
- Gently turn the vial between your fingers without shaking or causing bubbles, until all that powder has dissolved.
- Using a fresh syringe, pull-in air into your syringe then inject into the TB500 vial to create a vacuum (don’t inject air into your powder mixture).
- Then pull your TB-500 solution with your syringe from the vial.
- Gently tap on your syringe to release any air before injecting the solution. Then inject the dose into a site as close to your injury as possible (for this step you might need some assistance).
Since the primary purpose of TB500 supplement is for repairing and healing any wounds, a dosage of 2.0mg – 2.5mg has proven to be beneficial and contains a high success rate.
Other than in humans, TB 500 peptide is also used for in animals. In animal uses, the dose varies.
However, the most common dose used for is of six 10 mg injections that are administered at intervals of between 7 to 10 days. And for more intensive treatment, a dose of 20 mg is given each week. Also, the most popular dosage used for dogs is six 5 mg injections that are administered each week.
How to Use TB 500 For The Best Results?
Once you get your TB 500, you’ll need to reconstitute it before use. And as we’ve seen, the process is not complicated. There are different ways that you can use to deliver TB 500 supplement into your bloodstream.
However, one thing that you should always remember is to wipe the area you are about to inject and the rubber stopper. You can do so using an alcohol swab to help prevent bacterial infection and contamination.
To deliver TB500 into your bloodstream, you can choose either use intramuscular, intravenous, or subcutaneous injections.
Do not leave your mixed TB-500 to sit in the light or at room temperature as it’ll go bad. Therefore, to ensure it maintains the highest quality, you will need to keep it away from direct light and at frozen temperatures or refrigerated.
So how does each of these methods work?
The intravenous method isn’t for the faint-hearted as you have to insert the needle into your vein. This method can be rather painful since the veins targeted are in areas with sensitive skin, for instance, the back of your hand, your wrist or your elbow.
For best results, consider using this method only if you are under medical supervision or you aren’t faint of heart.
Yet another painful method which involves injecting the skin on the injured area.
Probably the simplest and even least painful method of the three. This method required that you pinch a small area of your skin anywhere on your body then insert the needle. To get optimal results, try targeting an area that is as close to your injury as possible.
Also, a great way for you to get the substance more effectively into your bloodstream is by massaging the area once you have injected it.
In so doing, it’ll help quicken the absorption and even make this peptide more efficient.
TB 500 Storage:
How you store your TB 500 supplement is very important and it’s taken care of in both the stage.
- Before reconstitution
That’s when this product is in for of the dried powder (also referred to as Lyophilized form).
You can store it for a maximum of 24 months when the powder is refrigerated at temperatures of between 36 to 48 Fahrenheit (or 2 to 9 degrees Celsius).
You can store it for a maximum of 3 months when you store it at room temperature at a maximum of 98.6 degrees Fahrenheit (that is 37 degrees Celsius).
You can store it for a max of 8 days when you store it at a maximum temperature of 45 degrees Celsius or 113 Fahrenheit.
- After Reconstitution
That is when you take the dried powder form of TB 500 and mix it with bacteriostatic water to allow for use.
This solution may be stored for at most 8 days and it should be kept under refrigeration at temperatures of between 36 to 46 Fahrenheit (that is 2 to 8 degrees Celsius). Note: Ensure that you don’t freeze it.
Things To Keep In Mind
It’s recommended that you administer 4 to 8 mg of TB-500 twice a week. If you are using a dose of 2 mg for each injection, you could use TB500 peptide between two and four times a week.
Since injecting this supplement subcutaneously (under a fat layer near the injury) is less painful, then this method is a great way for you to begin.
TB 500 moves systematically after it’s injected, meaning getting your dose in your abdomen can travel fast to where it’s needed. You could consider stacking the TB-500 peptide for enhanced healing benefits with BPC-157.
Remember that the type of TB-500 peptide that is sold online usually comes in a form of powder, and it should be added to the bacteriostatic water before use.
This is how you’ll get optimal results from the peptide. Also, make sure that you mix it thoroughly to get more TB500 into your bloodstream.
After your mixture is ready, you can use an insulin syringe to transfer it into your system. This makes it possible for you to administer the TB-500 in several ways that we have already looked at above.
Be sure to choose a method that works best for you and you can talk to your doctor for assistance and if you have any questions.
Where to Buy TB 500?
TB 500 is mostly available as Thymosin Beta-4 and is sold for research purposes only. As we have mentioned earlier, when you buy your TB-500, it’ll come in the form of a powder.
Thus, you’ll need to “reconstitute” using bacteriostatic water. When buying your TB500 peptide, always make sure you buy from a reputable provider like Nu Image Medical.
Be sure to talk to your doctor if you have any doubts before using this supplement.
So far, peptides have not received much research and most of the available information is either anecdotal evidence or derived from animal studies. This means that using peptides like TB-500 is more a calculated risk you take with caution.
Fortunately, there are many great resources available that you can look up for more information. But, the responsibility is still on you that you continue learning more about the newest research developments on this peptide.
Evidence shows that TB-500 may be beneficial in accelerating your recovery from wounds and injuries while supporting muscle growth.
Thus, it is worth it should you choose to try it out. When you decide to use TB500, make sure you at first use it under medical supervision and follow the recommended dosage.
Luke is ProvHosp’s in-house journalist interested in all things natural. A graduate of the University of Michigan’s Journalism program, Luke is always eager to get the next story of discovery in the field of health sciences.