MK 677, which is also called Ibutamoren Mesylate is what is known as a growth hormone secretagogue. Many people think that MK677 is a SARM (selective androgen receptor modulator), but it is not one.
Recently this product has become rather popular thanks to its ability to boost IGF-1 and growth hormone levels. Also, this is the main reasons why it’s presently being used for research – in treating lowered levels of the mentioned hormones. Even then, bodybuilders commonly use this compound as it helps enhance their muscle mass, strength and recovery.
Besides increasing IGF-1 and even growth hormone levels, there are many other benefits linked to Ibutamoren Mesylate that we’ll look at throughout this review.
In our MK-677 review, we will look at everything you should know about its benefits, dosing, possible side effects, Mk 677 cycles, stacks with other SARMs and even the results you can expect when using it.
So, why do people take MK-677? Is it safe? keep reading to find out. But first…
MK677 (Ibutamoren Mesylate ) is today developed medically to help fight growth hormone and also IGF-1 (insulin-like growth factor1 ) deficiencies among people of different ages.
Currently, the food & drug administration (FDA) categorizes it under investigational hence it’s still at the preclinical stage while waiting for the next step.
Although it’s not yet approved for use in the medical field and is not being prescribed yet, it does not mean that some research companies are not offering it to people who want to enhance their performance.
Athletes of different abilities and also average joes have used it and they have reported getting some amazing results.
How Does MK-677 Work?
This compound works by re-creating the effects of ghrelin, a hormone that occurs naturally in the body. Since it imitates Ghrelin, it activates the Ghrelin receptor which in turn stimulates your pituitary and also Hypothalamus to release Somatropin or HGH ( growth hormone) and the insulin-like growth factor (IGF). And with higher growth factor levels, you are likely to attain lean muscle mass growth.
In addition, this hormone is said to have the ability to induce a ravenous appetite. Not to mention, it regulates energy distribution in your body.
Besides, it affects how your body metabolizes fat. What’s more, it can influence your recovery rate from conditions like obesity and Type 2 diabetes.
If used on its own, this product can help increase HGH production without interfering with other hormones.
Those who take Ibutamoren Mesylate, like that it does not suppress their body’s existing growth hormone and testosterone levels, which is a big plus considering the benefits.
How to use Ibutamoren
Why use it instead of HGH?
The main advantage of taking MK677 (Ibutamoren Mesylate) over injecting the growth hormone, is that one helps increase your hormone levels while the other only shut you down.
There are several reasons you should look at it too. First, Ibutamoren Mesylate aka MK677 does not require to be mixed, injected and refrigerated as MK677 comes in capsule form.
Second is its cost. Good quality HGH is on the pricey side, while Ibutamoren costs only a fraction of the amount.
Why use it instead of peptides?
Again, the one reason you may want to take Ibutamoren instead of peptides for raising growth hormone levels is due to storage, injecting and mixing factors. Also, there has been a troubling tendency where peptide companies offer underdosed or even bunk products.
That being said, it is important that you research more about the brand you choose depending on the desired results and goal.
But, at this point, we would like to bring to your attention about Proven Peptide’s MK677, which may be stored for some years and not worry about this compound going rancid.
Fat loss and muscle gains
Ibutamoren is amazing for people who want to bulk up since it helps increase your appetite so much. This, in turn, allows you to increase your macros thus grow stronger and get bigger. Also, it can be used when you are cutting down body fat as it changes how your body metabolizes food.
Most users report that they shred up even when they don’t change their diets.
People who lift weights will enjoy the faster recovery it offers between workouts. Its users are also impressed by the gains in lean muscle mass and mild strength they get. Also, endurance athletes report that they notice a boost in the time they spend running.
Additionally, Ibutamoren helps in injury repair as well. And when stacked with TS Krill Oil by N2bm and N2jointrx then you’ll notice a big difference in how your soft tissues and joints feel.
People who struggle with an appetite can enjoy instant benefits by using Ibutamoren within week 1 or 2. Again, this product will also help you get better sleep and it works great for insomniacs.
Why Some People Take Ibutamoren
Let’s start by looking at some of the benefits to expect from using MK 677. Remember that it’s important that you have a legal source before using this product. So why use Ibutamoren?
To Build Muscle
MK-677 is well-known for its anabolic attributes. This allows it to support the lean gains which most athletes want to attain. These benefits can only be induced when MK 677 is administered orally once a day.
This is because it will not only increase IGF-1 levels but it also helps increase the production of your growth hormone as well.
When taken correctly, these benefits will help you grow your strength and muscle size while significantly decreasing the body fat in your body.
A controlled double-blind randomized trial was done with 24 obese males for 2 months and MK-677 was used as a treatment.
In 2 months, all the participants had an increase in BMR (basal metabolic rate) and they also grew more lean muscle.
Note that MK-677 does not work like SARMs do, for example, RAD-140, LGD-4033, Ostarine, etc. While MK-677 is frequently compared to SARMs, however, they work differently and they’re not the same.
Helps Prevent Muscle Wasting
In another controlled double-blind randomized trial, a study was conducted with 8 food-deprived volunteers.
These participants received MK-677 and their results showed to reverse muscle wasting and protein loss that they had experienced due to their diet as well as lifestyle.
The use of MK-677 has also shown to decrease the number of falls often suffered by elderly patients who have hip fractures.
From this randomized and controlled trial, the patients were able to experience improved gains while boosting their muscle strength.
Increase Bone Density
Studies have shown that Growth Hormone can enhance your bone density by influencing your bone turnover. Interestingly, this process starts by first reducing the bone turnover before increasing it.
What this then means is that it could take to about 12 months before you can see any results.
In another randomized double-blind controlled trial done with 24 obese men, MK-677 showed to increase the bone turnover as was expected.
And in another 3 double-blind controlled randomized trials, Ibutamoren was able to enhance the body’s ability to develop stronger bones in persons aged 65 years and above.
Another study carried out with 292 post-menopausal women showed that MK-677 can greatly improve bone strength by increased mineral density.
From this, it has been proven to be very helpful in combating osteoporosis among postmenopausal women.
Helps with Sleep
MK-677 has shown to better the quantity and quality of REM sleep for both young and even elderly participants in a randomized double-blind controlled trial study.
Other than the scientific evidence, there is lots of anecdotal evidence which supports this claim. Most users have also experienced better sleep patterns due to taking MK-677.
Keep in mind that sleep is a key part of bodybuilding. This is since it allows you to recover fast and gain the strength you require for your next training session.
Once we have gone through puberty, our bodies GH secretion levels tend to decline drastically. But, in taking MK-677 you can address this problem since it can boost GH and IGF-1 levels.
This is from a controlled double-blind randomized trial study that was carried out with 65 elderly males. The participants received a daily MK-677 dose and showed higher GH levels afterwards.
In another controlled double-blind randomized trial study that was done with 24 obese men and it showed similar positive results.
Since MK 677 (Ibutamoren) stimulates the ghrelin receptors, it can result in nootropic effects. With that said, there is no empirical evidence that suggests the compound offers any effects on your cognitive performance. But, what we know is that Ibutamoren can help enhance your brain function through indirectly influencing 2 mechanisms. These are:
Through increasing IGF-1 which helps enhance your memory retention and learning ability.
Through improved quality and quantity of REM sleep. Realize that sleep is essential in ensuring optimum cognitive function.
In a multicenter randomized double-blind controlled trial study done with Alzheimer’s patients, this study tried to find out this compound’s effects on this disease.
Regrettably, the outcomes were inconclusive, hence no cure yet for Alzheimer’s.
Prevents HGH Deficiency
As we have seen earlier, MK 677 ( Ibutamoren ) can help increase the production of IGFBP-3, IGF-1, and the growth hormone which helps children that struggle with hormone deficiencies.
The best part is that MK-677 can achieve this and not disturb other hormones in your body like insulin, cortisol, thyrotropin, glucose, thyroxine (T4), and triiodothyronine (T3).
However, it seems that the same does not apply to adult patients. From a controlled double-blind randomized trial conducted with severely Growth Hormone deficient adult men.
It showed that in addition to improving IGF-1 levels, these participants experienced raised insulin and glucose levels. Suffice to say that was a rare occasion when Ibutamoren actually disrupted other hormones.
With increased growth hormone levels in your body, your body’s potential tor rebuild your damaged tissue and heal wounds will be improved.
Therefore, the benefits of using MK677 when it concerns wound healing are remarkable. But, this specific benefit is shown on anecdotal evidence instead of scientific study.
This benefit is only supported by anecdotal and subjective evidence, however, there have been claims which point to MK-677 having the ability to cure hangovers. Thus more scientific research is needed to evidence this claim.
Improves Skin and Hair Quality
Since MK-677 has shown to effectively improve your Human Growth Hormone levels, it can also have positive effects on your hair and skin.
Growth Hormone has shown to act on your skin cells, which can provide a positive effect on cell quality. And this, in turn, will give you improved skin quality.
These are some of the main positive results you can expect when using Ibutamoren (MK 677). Something worth mentioning that most users have noted is an accelerated fat loss while taking this product.
Even then, at what doses can you look to enjoy these effects and benefits? Let’s now look at more information on the optimal dosages of taking MK-677.
MK 677 Dosages & Cycle
The dosage of MK 677 depends on the level of your experience. If you’re just starting, we recommend that you start rather low, for instance with 5mg a day. This will help you notice how your body reacts to this substance. From there, you can then bump your dose up to 10mg per day for the following next week.
You can do this after you notice that it’s working alright and your body can handle it well. Professionals can right away start with taking 10mg a day then increase their dosage to 20mg each day for the following seven weeks.
Keep in mind that MK677 should be taken for about 2 to 3 months at doses of 12.5 to 50mgs a day. With an average dose of 25mgs.
Mostly, MK-677 comes in liquid and capsule form. The recommended oral daily dose is up to 25 mg, however, you can decide to take it at once or split your dosage.
While there are many users who take bigger doses. But, we wouldn’t recommend that you try higher dosages as it can expose you to serious harmful side effects.
You do not have to use any PCT when you are off MK-677. Also, it’s suggested that you take a break from using this substance for about 2 months.
In so doing, your body will be able to naturally rebalance its hormones and since MK-677 does not affect testosterone and cortisol, the side effects are minimal.
When you use MK677 as a standalone, you will not need a Post Cycle Therapy, as mentioned, it does not interfere with the body’s hormones.
Did you know that MK677 stacks well with any selective androgen receptor modulator (SARM )
Some people prefer to stack Ibutamoren (MK-677) with SARMs and this is something that we also recommend you do. What’s more, MK-677 works best when stacked with Testolone and Cardarine, depending on if you want to bulk or cut.
When you wish to cut, you can stack Ibutamoren with Cardarine for optimal results. Cardarine is renown for increasing endurance and accelerating weight loss. Therefore, you will have no issues cutting by using this combination.
During the 8 week cycle, you need to take 20mg of Ibutamoren combined with 20mg of Cardarine a day. Note that this dose is only ideal for professional and intermediate bodybuilders. Thus, you’ll not need PCT after following this cycle.
If you prefer to bulk, then you can stack Ibutamoren with Testolone, a potent and powerful SARM that supports muscle gain and fat loss.
During an 8-week cycle, you can take 20mg of MK-677 combined with 10 to 15mg of Testolone. However, avoid doing this if you are still new to bodybuilding.
You’ll need a mini-PCT phase once you complete this cycle since Testolone affects the androgen receptors in your body. These receptors are responsible for the production of testosterone.
It’s recommended that you follow a 6 week PCT cycle. Also, you should take Clomid or Nolvadex during that cycle.
Anabolic Steroid Stacks
Also, it’s safe to stack MK 677 with anabolic steroids. Regardless of whether you wish to cut, bulk, gain lean muscle mass or gain strength.
One cool stack you could try if you are looking to body build is 25mgs a day of Ibutamoren + 150mgs each week of Testosterone Enanthate + 500mgs a week of Primobolan.
Who shouldn’t use Ibutamoren?
We do not recommend the use of Ibutamoren (MK677) for persons under 21 years. Also if you’re a tested athlete, then it’s best that you stay away from it. This is because this is considered cheating, and you could be tested for it.
Both men and women are safe to use MK 677. Also, those who are underweight or overweight can use it. All in all, there are few situations where it may not be okay to use this product.
Even then, if you are diabetic or have heart conditions, it’s best you avoid taking Ibutamoren.
MK 677 Side Effects
Generally, MK 677 has so far not produced many side effects for users to be worried about. However, certain groups of people may experience certain side effects that they should look out for.
People who have the vulnerability to insulin sensitivity or persons with Diabetes could be at risk if they use MK 677. The reason behind this is since the symptoms linked to these conditions might get exacerbated by using MK 677. Like with any other substance, the correct usage and dosing of MK 677 are key.
To some studies that were looking at how Ibutamoren (MK 677) increases your muscle mass, then your dosage plays a key role.
Also, the side effects resulting from using MK-677 are typically the result of two things: extended use and improper dosage.
The reported side effects resulting from using MK 677 are usually due to unnaturally high amounts of growth hormone in your body. And this can result from using too much too frequently. These side effects may include:
- Insulin resistance
- increased appetite
- Joint pain for someone who has previous medical conditions or heightened hormone levels
Possible higher levels of prolactin, which can, fortunately, be controlled. But when it’s dosed properly, the MK 677 side effects are minimal and even none when compared to the outcomes you get when using it properly.
What’s more, the benefits of using MK 677 can be noticed in a matter of days. For optimal results, you could consider stacking MK 677 with SARMS. We have looked at some of the best stacks for different outcomes above.
Where to Buy MK677
Be cautious where you buy MK677 because there are many fakes on the market. With that in mind, we recommend that you do your homework first before committing to a specific brand. While there are several places you can buy Ibutamoren Mesylate, the best one is Proven Peptides.
MK-677 has shown to offer many health benefits for people with certain conditions. Persons with reduced bone density, have a hard time sleeping at night, or have catabolic conditions can greatly benefit from using MK 677.
The potential of MK 677 secretagogue to efficiently secrete HGH and IGF-1 proves it to be a helpful tool for various groups of people.
has through many studies shown to benefit people who are obese, the elderly, insomniacs, those with reduced bone density, and many others.
For these groups of people, MK 677 is a useful tool for combating issues that result largely due to lower levels of IGF-1 and Growth Hormone.
Luke is ProvHosp’s in-house journalist interested in all things natural. A graduate of the University of Michigan’s Journalism program, Luke is always eager to get the next story of discovery in the field of health sciences.