Hormone replacement therapy has in recent times been making headlines, and for the right reasons. For instance, some studies, have determined that hormone replacement can fight belly fat. Such news is especially great for gym buffs and menopausal women everywhere.
However, each hormone replacement treatment does not offer the same results. While there are many different peptides available today on the market, two of the well-known peptides are Ipamorelin and CJC 1295.
What, benefits does each of these peptides offer? How does each work? And what side effects accompany each one?
Our natural Growth Hormone levels decrease drastically as we grow older. And unless it’s optimized naturally, these levels will keep declining, thus bringing along all the signs and even symptoms of aging.
With that in mind, keep reading to learn more about some important benefits and side effects of using Ipamorelin and CJC 1295. We’ll also look at why combining them makes a super combo.
What are Ipamorelin and CJC 1295?
When combined, the peptides CJC-1295 and Ipamorelin can be used effectively for anti-aging purposes and even by persons with inflammatory conditions, diseases or those with low IGF-1 levels.
We will later look at the benefits of CJC-1295 and Ipamorelin and how this combo works to boost your natural production of GH for enhanced fitness, energy, and overall health.
What is CJC-1295?
This is a synthetically produced peptide which can raise your levels of the plasma growth hormone. CJC-1295 is normally introduced into your body by use of subcutaneous injections. Sometimes, CJC-1295 is known as DAC: GRF. DAC is the acronym for Drug Affinity Complex, and GRF stands for growth hormone-releasing factor.
This substance can boost IGF-1 and growth hormone levels in both humans and animals.
The presence of DAC helps increase the half-life of this peptide (CJC-1295). At first, CJC 1295 was made for treating diseases and medical conditions in patients with muscle diseases, disorders, and also burn victims.
Nonetheless, CJC-1295 has gained much attention from many people like athletes for its amazing benefits and even minimal side effects while enhancing their performance both at the gym and on the field.
Mechanism Of Action
CJC-1295 is a mimetic of GHRH. It helps boost plasma growth hormone levels from somatotropic cells found in the pituitary gland in animal test subjects. Also, it does not alter its normal pulsation and does not inhibit the effects that somatostatin has.
It is due to this effect that GHRH products cannot be incorporated for anabolic purposes unless you combine them with a GHRP. Also, CJC-1295 helps improve protein synthesis which then can result in muscle growth.
Your body uses proteins to build muscles. This means, when your body synthesizes protein better, then it has more protein available to use as the building blocks for your muscles.
Then it comes as no surprise, that many bodybuilders depend on peptides like CJC-1295.
How Is CJC 1295 Administered?
So how is CJC 1295 ingested for people to enjoy its benefits?
CJC-1295 without DAC ( Modified GRF 1-29 ): 100mcg per injection and each vial comprise of 20 X 100 mcg doses. The Injection amount: when using 100mcg dosage for 1 ml of water – if injecting, use .05 ml per syringe. For .1 ml is to be used with 2 ml of water per syringe.
1000 mcg has to be injected every day about 1 to 3 times and is best when you inject it with 100-200 mcg of GHRP peptides.
When using CJC-1295 with DAC, then take 600 mcg at any time once a week.
You should inject 1 to 3 times every day and the best dose is if used with 100-200 mcg of GHRP peptides.
How to inject CJC-1295
For optimal results, subcutaneous injection is recommended.
First, wash your hands then gather all the materials.
- Use alcohol to clean the vial before your injection. Also, use an insulin syringe to get the desired dosage, then tap or flick the syringe. Doing so helps remove unwanted bubbles.
- To prevent infections you should use alcohol pads to wipe your skin before your injection.
- Then gently insert your needle into the fat, then inject the contents of the syringe.
- After you complete, wipe the injected area with alcohol, then toss away the syringe.
CAUTION: Before you inject CJC-1295, always start by mixing it with some bacteriostatic water. The Bacteriostatic agents help prevent bacteria from reproducing, to make injecting this peptide safer.
- It causes fat loss
- It boosts slow-wave sleep
- It increases your performance
- It offers anti-aging properties
CJC-1295 Side Effects
So far we have looked at the benefits that this peptide offers. Next, look at the possible side effects of using CJC 1295 as well.
Here are a few of these side effects:
- Low blood sugar
- Long, vivid dreams
- Nausea (uncommon)
- Occasional lightheadedness
- Weakness in your body joints
While there are many other side effects, we recommend that you do your research before deciding whether these peptides are right for you.
TIP: Cautiously regulate the number of CJC-1295 you inject. When you are starting, we suggest that you begin by using the smallest dosage possible.
At this stage, be sure to measure your body’s reaction to the drug.
Once you’ve administered it for some time, determine whether or not the body can handle higher doses. Following this approach can help reduce the severity of any side effects you might experience.
What Is Ipamorelin?
Ipamorelin is also a peptide. Peptides are amino acid chains that are building blocks for muscle fibres and proteins. The long description of Ipamorelin is GHRP (Growth Hormone Releasing Peptide).
This is among the cleanest and safest peptides that produce growth hormone. Therefore, it is considered helpful to more people that have more conditions compared to other GHRPs – peptides.
Also, Ipamorelin is notable for its increased specificity, meaning that it can be more targeted.
Ipamorelin generates higher growth hormone secretion, and it does this without increasing your appetite and also the less desired hormones such as prolactin, cortisol, aldosterone and acetylcholine.
And this is something that other peptides belonging in its class do. Good thing, it’s been well-tolerated by different groups of users.
Mechanism Of Action
Ipamorelin imitates the GHRP (GH releasing peptide) Ghrelin through binding to GHRP receptors and activates the release of GH. Unlike other compounds that stimulate your pituitary GH system like GHRP-6 and -2, Ipamorelin is more specific in its activation.
It’s also metabolized slower compared to other GHRPs, which makes it more stable hence more effective for longer.
How Ipamorelin is Administered?
When it comes to injecting Ipamorelin, there are two choices for you. You could either inject this peptide subcutaneously or opt for the intramuscular method. With the subcutaneous method, you will need to stick the needle directly into your skin’s fat layer. And for the intramuscular method, you will stick the needle directly into the muscle tissues.
Both these administrations are equally valid. Therefore, users can opt for a method that they’re more comfortable with.
Realize that everyone’s body is different, hence administer your Ipamorelin as directed by your doctor. In general terms, the Ipamorelin dosage averages the pattern below:
The dose for each injection is 200mcg. Thus injections for each vial is 10 x 200mcg doses
Amount to Inject will depend on the water-to-Ipamorelin ratio. For instance:
When you take 1ml of water, mix a 200mcg dose at 0.10ml ( that is 10 units marking on your Insulin syringe).
When you take 2ml of water, mix 200mcg dose at 0.20ml (or at 20 units mark on the syringe)
Your injection frequency needs to be done at the same, that helps build a routine. Best times to inject Ipamorelin is in the morning, either pre- or post-workout as well as before bedtime.
- For beginners administer 1 dose a day
- For intermediate users 2 doses a day
- And for advanced users 3 doses each day
Like when using CJC 1295, always start slow when administering Ipamorelin. Gradually, keep adjusting your dose to suit your body. In so doing, you will be giving your body the time to adjust to this peptide hormone.
- Accelerated growth of lean muscle mass
- Quicker weight loss
- Growth of healthy hair, skin, and nails
- Provides anti-aging effects
- Lowering blood pressure
- Decreases stress and anxiety
Ipamorelin Side Effects
Ipamorelin works by negating some of the nasty CJC 1295 side effects. Unfortunately, this peptide comes with its share of side effects.
But the good news is:
Ipamorelin side effects aren’t common. Still, they are minor as compared to those from CJC 1295.
For example, Ipamorelin can cause headaches or vertigo. However, the effects will depend on the amount of Ipamorelin you inject into your body.
This means, if you’re administering too much of this peptide, you’re more prone to experience headaches.
How is Peptide Therapy Different from HGH Therapy?
The Human Growth Hormone ( HGH ) Peptides like Ipamorelin and CJC1295 do not replace your body’s natural growth hormone production. Instead, they naturally help increase your body’s production of the growth hormone.
This is different from using human growth hormone injections since the direct HGH therapy inhibits your body’s natural production of growth hormone.
To make things worse when using direct HGH therapy, it can lead to a complete imbalance of the other hormones in the body.
And this normally results in the undesirable side effects such as liver damage, carpal tunnel syndrome, cancerous tumours and in men having enlarged breasts.
Combining CJC & Ipamorelin for Peptide Therapy
So far, we have looked at what CJC1295 and Ipamorelin are. Next, we’ll talk about peptide therapy in detail.
So, what is peptide therapy?
First off, peptides are amino acid chains that help control the main body functions. Peptides have immense effects in your body, from building proteins to even transporting cells. Keep in mind that peptides are very important that peptide imbalances and deficiencies can wreak havoc in your body.
This means that your body becomes susceptible to myriad disorders and diseases when your peptide levels are too low or too high.
And these are instances where peptide therapy may come in. When you correct peptide levels by use of peptide therapy, you will be restoring your body’s equilibrium, reducing the risks of developing specific illnesses.
So where does CJC1295 & Ipamorelin come in?
The two peptides, Ipamorelin and CJC 1295 happen to be among the most common peptides. What’s more, they even complement each other. Meaning, they work well together, that people often use them together.
So what can you expect when you use these two peptides together?
- Stimulate the release of growth hormone,
- Decreasing the signs and symptoms of aging
- Boosts the efficacy of injury repair
- Increased bone strength and density
- Supports fat loss
As we have mentioned above, some benefits from Ipamorelin counter some of the side effects from CJC 1295. The former’s capability to contain the side effects from the latter gives this pair a great synergy.
CJC 1295 and Ipamorelin for Enhanced Growth Hormone Levels
As we’ve stated earlier, peptides play a key role in your body’s primary systems and processes. One of these systems is your endocrine system which encompasses all your glands in your body that produce hormones.
The Ipamorelin and CJC combo are particularly advantageous to this system. This is because it boosts the production of proteins that enhance your bodily functions which are specific to your endocrine systems.
And when you have a top-tier endocrine system, then you will be able to develop more muscles mass.
What Are The Benefits of CJC 1295 & Ipamorelin?
The combination of CJC-1295 and Ipamorelin peptides will offer you many benefits. Studies have even shown that they offer results that are therapeutic and safe for healthy adults.
Benefits of combining CJC 1295 & Ipamorelin include:
Increased strength and lean muscle mass
Since Ipamorelin and CJC2195 stimulate the production as well as secretion of GH, they help increase your lean muscle growth, build strength more and also reduce body fat.
Supports Muscle Recovery and cell repair from injuries
The use of CJC 1295 and Ipamorelin can help in muscle recovery post workouts. And this allows for quick progression and often more fat loss. When you use the right bio-identical hormone replacement program, you will have an improved overall state of well-being. This follows your recovery time ( I.e soreness) and healing of acute musculoskeletal injuries.
Increased Energy Levels And Overall Vitality
Additional benefits of using CJC 1295 & Ipamorelin include the broad anti-aging properties, and even improved sleep patterns, mood, energy levels, bone density, body composition and immune function. Also, Ipamorelin can be used in attaining a more energetic and youthful state through long-term use ( often 6 to 12 months).
Helps burn body fat
CJC 1295/Ipamorelin helps increase fat metabolism which leads to general improvements in your body composition. As we stated with increased muscle mass, your body’s metabolic rate is increased leading to burning more calories throughout the day.
Increased Sex drive
Sex drive is huge and it is equally a key part of your health, your mood, and everything. Therefore, when you cannot function properly sexually, then this can even affect your mental well-being.
Strengthens your Immune System
People who have used this super peptide combo have reported that following this program they rarely get sick. This can be a tremendous benefit for when you’re trying to achieve optimal health. And this can be achieved when you have a strong immune system.
Improves your cognition and memory function
This is an improved general benefit to your body and wellness when you are on Ipamorelin and CJC 1295. And this includes improved focus and having sharpness and feeling mental clarity throughout your day.
Improved Insulin Sensitivity
CJC 1295 & Ipamorelin helps improve your insulin sensitivity therefore it reduces your body’s triglycerides. Also, high blood sugar levels are reduced and this helps burn off more body fat. CJC 1295 (also known as GRF 1-29) a 29-amino acids peptide hormone, that primarily functions as a GHRH analog.
Also, research indicates that CJC 1295 helps stimulate the secretion of GH. Due to this, you will have a youthful and also amplified production of GH as well as IGF-1 with little to no effects on your prolactin and cortisol levels.
Since it is a pentapeptide, Ipamorelin is made up of five amino acids, and it mimics your body’s natural Growth Hormone release.
Again, Ipamorelin is an analogue of hormone Ghrelin and a GHRP. It stimulates GH release and boosts the number of somatotrophs (cells that support GH release) by suppressing somatostatin in a GH pulse.
And this makes a great option for people who want to maintain a steady and enhanced release of GH.
To get the benefits of higher levels of the growth hormone and afterwards those of Insulin-like Growth Factor1 (IGF-1) without suffering any side effects.
CJC-1295 with Ipamorelin
Oftentimes, CJC-1295 with DAC is used together with Ipamorelin due to their synergistic effects and also increased GH production levels. When you following CJC-1295’s weekly cycle, you’ll include the Ipamorelin evening injections (note that this might cause drowsiness).
This can reduce cortisol as well as prolactin levels, as compared to GHRP 6 and GHRP 2. also, you can use Ipamorelin stacked with HGH, about 2 to 3 times each week, for a prolonged cycle.
You could try using Ipamorelin doses of 200 – 300 mcg, 2 to 3 times every day with subcutaneous injections.
It’s best to start administering lower doses, to minimize the side effects (often rush or headaches). it is recommended you inject 20 – 30 minutes pre-workout, due to the pulse in the growth hormone. Hence, it will offer you the best results.
Ipamorelin also works slower than GHRP, thus GH level spikes are not noticeable as quickly. This slower release is also natural and will offer you prolonged effects.
Additionally, those on restricted calorie consumption diets, have not reported of increased hunger levels after using GHRP 6 or Ipamorelin.
When Should I Take CJC 1295 & IPAMORELIN?
It’s recommended that you take Ipamorelin and CJC 1295 at night to optimize your body’s natural cycle of the growth hormone. Due to this, it will stimulate your pituitary gland during the REM sleep.
Why Should CJC 1295 & Ipamorelin Be Administered Together?
The combination of CJC 1295/Ipamorelin is best taken together for you to maximize the level of growth being provided to your body. They also create safer and therapeutic anti-aging benefits. Even some would refer to it as the fountain of youth!
Where To Buy Peptides
You can buy CJC 1295 & Ipamorelin from Nu Image Medical. Buy peptides that are USA-made for the reliability of their research. While some wellness or health professionals will order the prescription, then have it send to their clinic or facility. And you can then pick it from there. And others will suggest that you get your prescription to a pharmacy they trust to create the best quality blend for you.
Nonetheless, some clients get theirs online—but be cautious that you trust the provider and their delivery method ( package delivery, mail etc.)
It’s always recommended that you work with your doctor to guide you to the right source of quality products that are produced in safe, clean environments.
And if you choose to work with Nu Image Medical, they have their certified doctors who can help you choose the right product for your needs.
The combination of CJC-1295 and Ipamorelin can be a beneficial regenerative medicine. This combo’s synergy is phenomenal that scientists are optimistic about it.
You should note that, while various scientific studies done on animal test subjects yielded potentially positive outcomes when using a blend of CJC-1295 & Ipamorelin.
This peptide combo is still under research and is not for human consumption. Unless used under prescription by a certified health practitioner.
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Luke is ProvHosp’s in-house journalist interested in all things natural. A graduate of the University of Michigan’s Journalism program, Luke is always eager to get the next story of discovery in the field of health sciences.